Vasculopathy in the setting of cardiorenal syndrome: roles of protein-bound uremic toxins
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چکیده
منابع مشابه
Vasculopathy in the setting of cardiorenal syndrome: roles of protein-bound uremic toxins.
Chronic kidney disease (CKD) often leads to and accelerates the progression of cardiovascular disease (CVD), while CVD also causes kidney dysfunction. This bidirectional interaction leads to the development of a complex syndrome known as cardiorenal syndrome (CRS). CRS not only involves both the heart and the kidney but also the vascular system through a vast array of contributing factors. In a...
متن کاملCardiorenal syndrome: the emerging role of protein-bound uremic toxins.
Cardiorenal syndrome is a condition in which a complex interrelationship between cardiac dysfunction and renal dysfunction exists. Despite advances in treatment of both cardiovascular and kidney disease, cardiorenal syndrome remains a major global health problem. Characteristic of the pathophysiology of cardiorenal syndrome is bidirectional cross-talk; mediators/substances activated by the dise...
متن کاملProtein-bound uremic toxins: a long overlooked culprit in cardiorenal syndrome.
Protein-bound uremic toxins (PBUTs) accumulate once renal excretory function declines and are not cleared by dialysis. There is increasing evidence that PBUTs exert toxic effects on many vital organs, including the kidney, blood vessels, and heart. It has been suggested that PBUTs are likely to be a potential missing link in cardiorenal syndrome, based on the high incidence of cardiovascular ev...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Heart and Circulatory Physiology
سال: 2017
ISSN: 0363-6135,1522-1539
DOI: 10.1152/ajpheart.00787.2016